Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity.
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Date
2012-04
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Abstract
Background: Strychnos nux-vomica, commonly known as kuchla, contains strychnine and brucine as main constituents.
Minor alkaloids present in the seeds are protostrychnine, vomicine, n-oxystrychnine, pseudostrychnine, isostrychnine,
chlorogenic acid, and a glycoside. Seeds are used traditionally to treat diabetes, asthma, aphrodisiac and to improve appetite.
Objective: The present study was aimed to evaluate the various pharmacognostical characters and antidiabetic activity
of S. nux-vomica seed. Materials and Methods: Pharmacognostical characters were performed as per the WHO guideline.
Extraction was carried out in petroleum ether, chloroform, alcohol, hydroalcoholic, aqueous, and phytochemical constituents
present in extracts were detected by different chemical tests. Among these extracts hydroalcoholic, aqueous extracts were
evaluated for antidiabetic activity on the basis of extractive yield and phytoconstituents, in alloxan-induced diabetic rats
using gliclazide as standard. Results: Various analytical values of S. nux-vomica extract were established. Phytoconstituents
present in S. nux-vomica extracts were detected. Conclusion: S. nux-vomica extracts show antihyperglycemic activity
in experimental animals.
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Keywords
Antidiabetic activity, alloxan, extract, kuchla
Citation
Bhati Rajesh, Singh Anupama, Saharan Vikas Anand, Ram Veerma, Bhandari Anil. Strychnos nux-vomica seeds: Pharmacognostical standardization, extraction, and antidiabetic activity.Journal of Ayurveda and Integrative Medicine. 2012 Apr-June; 3(2): 80-84.