Trace elements; copper, zinc and selenium, in breast cancer afflicted female patients in LAUTECH Osogbo, Nigeria.
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Date
2015-01
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Abstract
BACKGROUND: There is an indication of the possibility of the direct or indirect influence of trace element in the development and prevention
of malignant diseases, the contribution of the trace elements in the etiology of breast cancer has been under scrutiny. AIMS: The aim of this
study was to determine the serum concentration of trace element in serum of female patients with breast cancer in comparison with healthy
controls. SETTINGS: Breast Clinic of the Department of Surgery LAUTECH University teaching hospital Osogbo, in south‑western Nigeria.
MATERIALS AND METHODS: A cross‑sectional age matched controlled prospective study wherein the venous blood sample of 30 patients
with breast cancer and 30 healthy volunteers as controls were analyzed using atomic absorption spectrophotometry. The collected data were
analyzed using statistical package for the social sciences (SPSS Inc) 16. RESULT: The mean serum concentration of the copper, zinc and
selenium were 95.3 ± 4.9 ug/dl and 65.2 ± 15 ug/dl, 62.7 ± 15.7 ug/dl and 93.5 ± 7.2 ug/dl, 45.0 ± 4.6 ug/l and 76.4 ± 8.9 ug/l in the two groups
respectively. The concentrations of copper and copper‑zinc ratio (C/Z) were significantly higher in the cancer bearing group compared to the
controls (C/Z 1.6 ± 0.5 against 0.70 ± 0.14 the P < 0.01). The concentration of zinc and selenium in the venous blood of the breast cancer
patients showed inverse relationship while that of the control showed a direct relationship (−0.03 against 0.09). In the breast cancer patients
the correlation of copper and zinc, copper and selenium and zinc and selenium showed inverse relationships, none of the relationships was
statistically significant. CONCLUSION: We found a significant association between the serum concentration of trace elements and breast cancer.
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Keywords
Copper, female breast cancer, Nigeria, Osogbo, selenium, zinc
Citation
Adeoti M L, Oguntola A S, Akanni E O, Agodirin O S, Oyeyemi G M. Trace elements; copper, zinc and selenium, in breast cancer afflicted female patients in LAUTECH Osogbo, Nigeria. Indian Journal of Cancer. 2015 Jan-Mar; 52(1): 106-109.