Hepatoprotective activity of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats.
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Date
2011-07
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Abstract
The present study aims to evaluate the hepatoprotective activity of ethanol extract of Symplocos racemosa (EESR) bark on
carbon tetrachloride (CCl4)-induced hepatic damage in rats. CCl4 with olive oil (1 : 1) (0.2 ml/kg, i.p.) was administered
for ten days to induce hepatotoxicity. EESR (200 and 400 mg/kg, p.o.) and silymarin (100 mg/kg p.o.) were administered
concomitantly for fourteen days. The degree of hepatoprotection was measured using serum transaminases (AST and ALT),
alkaline phosphatase, bilirubin, albumin, and total protein levels. Metabolic function of the liver was evaluated by thiopentoneinduced
sleeping time. Antioxidant activity was assessed by measuring liver malondialdehyde, glutathione, catalase, and
superoxide dismutase levels. Histopathological changes of liver sample were also observed. Significant hepatotoxicity
was induced by CCl4 in experimental animals. EESR treatment showed significant dose-dependent restoration of serum
enzymes, bilirubin, albumin, total proteins, and antioxidant levels. Improvements in hepatoprotection and morphological
and histopathological changes were also observed in the EESR treated rats. It was therefore concluded that EESR bark is
an effective hepatoprotective agent in CCl4-induced hepatic damage, and has potential clinical applications for treatment
of liver diseases.
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Keywords
Carbon tetrachloride, hepatoprotective, Symplocos racemosa, silymarin
Citation
Wakchaure Dhananjay, Jain Dilpesh, Singhal Abhay Kumar, Somani Rahul. Hepatoprotective activity of Symplocos racemosa bark on carbon tetrachloride-induced hepatic damage in rats. Journal of Ayurveda and Integrative Medicine. 2011 July-Sept; 2(3): 137-143.