Evaluating the relation between patients‑related factors and dissected lymph node ratio in gastric cancer.
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Date
2015-01
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Abstract
BACKGROUND: Gastric cancer is a forth common malignancy world‑wide and the second most common cause of cancer‑related deaths. According
to the current International Union Against Cancer staging system, nodal status is categorized based on the number of metastatic lymph nodes (LNs).
Some groups have recently proposed the metastatic lymph node ratio (MLR) (the ratio between metastatic LNs and total dissected LNs; MLR)
as an alternative prognostic factor. The aim of the present study is to evaluate the relationship between MLR and different clinico pathologic
factors including patients’ age, tumor grade, stage, sites of involvement and disease prognosis. METHODS: A total of 70 patients with gastric
adenocarcinoma who underwent gastrectomy with negative margin and LN resection during 2004‑2009 and were referred to Radiotherapy‑Oncology
Department of Name of Hospital, Name of City, were included in the study. MLR status was divided to five groups. Collected data were analyzed
with SPSS 16 (SPSS Inc., Chicago, IL, USA). RESULTS: The difference between MLR groups in age was significant; older patients had lower
MLR (P = 0.01). The ratio of male to female was 5.3, which indicated higher prevalence of gastric cancer in males. The difference between MLR
groups for tumor location, tumor stage, disease free periods and tumor T stages were not significant. A significant relation existed between different
stages of LN involvement and MLR; and also between cancer stages and MLR. CONCLUSION: We found a significant relation between MLR and
cancer stage and metastatic LN. Due to small sample size and short period of follow‑up, we could not find significant relation between MLR and
other factors such as depth of tumor invasion, disease free period and tumor grading. In conclusion with regards to our results and other similar
studies’ results, we acknowledge the importance of MLR in determining patients’ prognosis in gastric cancer.
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Keywords
Breast cancer, dissected lymph nodes, metastatic lymph nodes
Citation
Saedi H S, Fanipakdel A, Shafaghi A, Ghorbani S. Evaluating the relation between patients‑related factors and dissected lymph node ratio in gastric cancer. Indian Journal of Cancer. 2015 Jan-Mar; 52(1): 48-51.