Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities.
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Date
2010-01
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Abstract
Ayurveda, the Indian holistic healthcare system encompasses traditional medicines with a principle of creating harmony
and maintaining balance within the natural rhythms of the body. Rasayana is one of the branches of Ayurveda frequently
used as rejuvenant therapy to overcome many discomforts and prevent diseases. It has been reported that rasayanas have
immunomodulatory, antioxidant and antitumor functions. However, the genotoxic potential of many rasayanas remains
to be evaluated. The present study was undertaken to assess the role of Brahma rasayana(BR) on genotoxicity in vivo in
a mouse test system. The older mice (9 months) were orally fed with rasayana for 8 weeks. The treated groups showed
no signs of dose-dependent toxicity at the dosage levels tested. The body weight loss/gain and feed consumption were
unaffected at tested doses. Furthermore, sperm abnormalities and chromosomal aberrations were insignificant in the
treatment group when compared to controls. However, there was a marginal increase in sperm count in the BR treated
animals. These findings clearly indicate that there are no observed adverse genotoxic effects elicited by BR in experimental
animals such as mice.
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Keywords
Aging, Brahma rasayana, chromosomal aberrations, genotoxicity, sperm abnormalities
Citation
Guruprasad K P, Mascarenhas Roshan, Gopinath P M, Satyamoorthy K. Studies on Brahma rasayana in male swiss albino mice: Chromosomal aberrations and sperm abnormalities. Journal of Ayurveda and Integrative Medicine. 2010 Jan-Mar; 1(1): 40-44.