Comparison of Ondansetron Used Alone and in Combination with Dexamethasone as a Prophylaxis for Postoperative Nausea and Vomiting Following Laparoscopic Cholecystectomy.
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Date
2014-01
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Abstract
Postoperative nausea and vomiting (PONV) is common after anaesthesia and surgery. In patients undergoing
laparoscopic cholecystectomy (LC) without antiemetic prophylaxis, the incidence can be as high as 76% which would
cause unexpected delay in hospital discharge. This study was designed to compare the efficacy of the ondansetron
alone with combination of ondansetron and dexamethasone the given as prophylaxis for PONV in patients
undergoing laparoscopic cholecystectomy. One hundred patients undergoing elective laparoscopic cholecystectomy
were selected and randomly divided into 2 groups of 50 each. Group I received 4mg of ondansetron intravenously
(iv), whereas Group II received ondansetron 4mg and dexamethasone 4mg just before induction of anaesthesia.
Postoperatively, the patients were assessed for episodes of nausea, vomiting and need for rescue antiemetic. Complete
response defined as no nausea and vomiting during first 24 hours, was noted in 76% of patients in Group I and in
92% of patients in Group II. Rescue anti emetic requirement was less in Group II (4%) than Group I (20%). So it can
be concluded that the combination of ondansetron and dexamethasone is more effective in preventing PONV in
patients undergoing laparoscopic cholecystectomy than ondansetron alone.
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Keywords
Ondansetron, Dexamethasone, Laparoscopic Cholecystectomy, Postoperative nausea vomiting (PONV)
Citation
Sanjowal L, Biswas S K, Saha J C. Comparison of Ondansetron Used Alone and in Combination with Dexamethasone as a Prophylaxis for Postoperative Nausea and Vomiting Following Laparoscopic Cholecystectomy. Faridpur Medical College Journal. 2014 Jan; 9(1): 3-6.