Familial Hypoparathyroidism with Pregnancy- Challenging Issue for Patient as well as for Physician.
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Date
2011-07
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Abstract
Familial hypoparathyroidism is a rare cause of hypoparathyroidism. It may be x-linked recessive, autosomal dominant
or autosomal recessive. In autosomal dominant hypoparathyroidism there is activating mutation of the calcium sensing
receptor leading to inhibition of Parathormone (PTH) secretion at inappropriately low serum ionized calcium level.
The disease often manifests in the first decade but may appear later. Clinical signs primarily involving neuromuscular
disturbances including generalized seizure. Management of pregnancy in hypoparathyroidism is challenging as both
under treatment and over treatment is dangerous for fetus. Treatment of hypoparathyroidism in pregnancy includes
combination of oral calcium supplementation with calcitriol with an aim to keep serum calcium within normal range.
Here we discussed a case of 21 year pregnant lady with familial hypoparathyroidism with successful delivery of a
healthy baby.
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Keywords
Hypoparathyroidism, Hypocalcaemia, Hyperphosphataemia, Epilepsy
Citation
Islam M M S U, Mubin S, Sarker M N, Ahmed D S, Barman R C, Siddiqui F M. Familial Hypoparathyroidism with Pregnancy- Challenging Issue for Patient as well as for Physician. Faridpur Medical College Journal. 2011 July; 6(2): 113-115.