Guillain-Barre´ Syndrome and Campylobacter jejuni Infection: A Review.
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Date
2014-01
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Abstract
Guillain-Barre´ syndrome (GBS), a neurologic disease that produces ascending paralysis, affects people all over
the world. Acute infectious illness precedes 50%-75% of the GBS cases. Although many infectious agents have
been associated with GBS, the strongest documented association is with Campylobacter infection. The first line of
evidence supporting Campylobacter infection as a trigger of GBS is anecdotal reports. The second line of
evidence is serological surveys, which have demonstrated that sera from GBS patients contain anti
Campylobacter jejuni antibodies, consistent with recent infection. Finally, culture studies have proven that a high
proportion of GBS patients have C. jejuni in their stools at the time of onset of neurological symptoms. One of
every 1058 Campylobacter infections results in GBS. Sialic acid containing lipooligosaccharides (LOS)
biosynthesis gene locus are associated with GBS and the expression of ganglioside mimicking structures. GM1a
was the most prevalent ganglioside mimic in GBS associated strains. Molecular mimicry between C. jejuni LOS
and gangliosides in human peripheral nerves, and cross-reactive serum antibody precipitate the majority of GBS
cases in Bangladesh, like worldwide.
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Keywords
Campylobacter jejuni, Guillain-Barre´ syndrome, molecular mimicry, ganglioside
Citation
Mawla Nurun Nahar, Sultana Shahin, Akhter Nayareen. Guillain-Barre´ Syndrome and Campylobacter jejuni Infection: A Review. Delta Medical College Journal. 2014 Jan; 2(1): 28-35.