Effect of preoperative statin therapy on early postoperative memory impairment after off‑pump coronary artery bypass surgery.
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Date
2016-01
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Abstract
Context: Frequent incidence of early postoperative memory impairment (POMI) after cardiac surgery
remains a concern because of associated morbidity, impaired quality of life, and increased health care
cost. Aim: To assess the effect of preoperative statin therapy on POMI in patients undergoing off‑pump
coronary artery bypass (OPCAB) surgery. Setting and Design: Prospective observational study in a tertiary
level hospital. Methods: Sixty patients aged 45–65 years undergoing OPCAB surgery were allocated into
two groups of 30 each. Group A patients were receiving statin and Group B patients were not receiving
statins. All patients underwent memory function assessment preoperatively after admission to hospital and
on the 6th postoperative day using postgraduate institute memory scale. Statistical Analysis: Appropriate
tests were applied with SPSS 20 to compare both groups. The value P < 0.05 was considered statistically
significant. Multiple regression analysis was performed with confounding factors to determine the effect
on memory impairment. Results: Patients in Group A showed significant postoperative deterioration in
6 of the 10 functions and in Group B showed deterioration in 9 of 10 functions tested compared to preoperative
scores. Intergroup comparison detected less POMI in Group A compared to Group B and was statistically
significant in 8 memory functions. Multiple regression analysis detected statin as an independent factor in
preventing memory impairment. Conclusions: Preoperative statin therapy attenuates the early POMI in
patients undergoing OPCAB. Future long‑term studies will define the efficacy of statin on POMI.
Description
Keywords
C‑reactive protein, Coronary artery bypass grafting, Memory function, Postoperative cognitive dysfunctions, Statins
Citation
Das Sambhunath, Nanda Sunil K, Bisoi Akshya K, Wadhawan Ashima N. Effect of preoperative statin therapy on early postoperative memory impairment after off‑pump coronary artery bypass surgery. Annals of Cardiac Anaesthesia. 2016 Jan; 19(1): 38-44.