Simple Reaction Time: Simple Measure To Quantify Quality of Life of Epileptics.
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Date
2011-07
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Abstract
The most activities of CNS are initiated by sensory experience emanating from receptions from eyes and
ears and causes immediate reaction from brain. In epileptic patient, neuronal metabolic disturbances
produces prolonged depolarization and require antiepileptic drugs to stabilized seizure which decreases
responsiveness of neurons to excitation and doesn't necessarily correct the specific etiology of seizure.
Considering all these factors, there is need to measure quality of life in patients in order to optimize the
outcome by more appropriate intervention, hence simple reaction time (RT) studies for Red, Green,
Indigo colors and high and low frequency auditory stimuli was carried out on 40 epileptic subjects (F-20&
M -20) and compare with age and sex matched controlled. RTs were found to be delayed in female but
failed to reach significance. (Red=173.85±27.63, Green = 175±26.22, Indigo=174.25±24.58,
High=171.20±23.63, Low= 177.60±26.13). In males RT for red color was highly significant and rest of
parameters was insignificant. (Red=196.40±41.72 {p-0.06}, green=193.45±52.72 Indigo=192.40±40.19,
high=187.90±22.45, low= 201.00 ±50.64). The RTs were insignificantly shortened in female epileptic
when compared with male epileptics. Also we found significant rise in male epileptics taking polytherepy.
The reaction time shows insignificant effect on prolonged use of drugs but that has to be verified with
further studies. In concluding, unpleasant effects of drugs can be reduced with meticulous selection and
proper dose of AED. This study also suggests reaction analyzer as a better non invasive alternative tool
for regular evaluation of hypo reflexes in epileptic patients.
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Keywords
Reaction time, Antiepileptic Drugs, Epilepsy, Polytherepy
Citation
Tirpude Rakhee M, Gajbhiye Ipr. Simple Reaction Time: Simple Measure To Quantify Quality of Life of Epileptics. JK Science Journal of Medical Education and Research. 2011 Jul-Sept;13(3): 135-140