Effect of Combined Oral Contraceptive Pill on FVC, FEV1 and FEV1/FVC%.
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Date
2015-06
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Abstract
Background: Combined oral contraceptive pill (COCP) is the most commonly used contraceptive
method in Bangladesh. This COCP may have some effects on different organs including lungs.
Objective: To observe the effects of combined oral contraceptive pill (COCP) on FVC, FEV1 and FEV1/
FVC% in apparently healthy women receiving COCP. Methods: This cross sectional study was carried
out in the Department of Physiology, Sir Salimullah Medical College (SSMC), Dhaka between July
2013 and June 2014. A total 30 apparently healthy young women, age ranged 20 to 30 years were
included in this study who were combined oral contraceptive pill users (COCP-U) for at least 6
months. Thirty age and BMI matched combined oral contraceptive pill nonusers (COCP-NU) were
taken as control. FVC, FEV1 and FEV1/FVC% of all the subjects were measured by digital spirometer.
Statistical analysis was done by Independent sample ‘t’ test. Results: FVC (p<0.001), FEV1 (p<0.001)
were significantly higher whereas, FEV1/FVC% (p<0.05) was significantly lower in COCP-U than
those of COCP-NU. Moreover, the mean serum estrogen (p<0.001) and progesterone (p<0.05) levels
were also significantly higher in COCP-U in comparison to those of COCP-NU. Conclusion: From the
result of this study it can be concluded that COCP have beneficial effects on some pulmonary function
parameters.
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Keywords
Pulmonary function parameters, Estrogen, Progesterone
Citation
Islam Farhana, Jahan Nasim, Sultana Nayma. Effect of Combined Oral Contraceptive Pill on FVC, FEV1 and FEV1/FVC%. Journal of Bangladesh Society of Physiologists. 2015 June; 10(1):21-25.