Relationship of Sympathetic Dysfunction with Disease Duration In Female Rheumatoid Arthritis Patients.
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Date
2015-06
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Abstract
Background: Association of increased cardiovascular morbidity and higher sympathetic activity in
patients with Rheumatoid arthritis (RA) has been well recognized. Objective: To assess sympathetic
nerve function status in Rheumatoid arthritis patients and its relationship to duration of the disease.
Methods: This study was carried out in the dept of Physiology Bangabandhu Sheikh Mujib Medical
University (BSMMU), Dhaka during 2010.Sixty female RA patients aged 18-50 years with duration of
disease from 1 to 10 years was selected from Rheumatology wing of Medicine OPD of BSMMU. Age
and BMI matched female apparently healthy subjects were control. Sympathetic nerve function status
was assessed by blood pressure response to orthostatic test and sustained hand grip isometric
exercise test. In these two tests, fall in systolic blood pressure (SBP) and rise in diastolic blood
pressure (DBP) respectively estimates sympathetic reactivity. For statistical analysis, unpaired students
t test and pearsons correlation coefficient test was applied. Results: Mean values of fall of SBP was
higher and rise of DBP was lower in RA patients compared to control which was statistically (P<0.001)
significant. Again rise of DBP was negatively and fall of SBP was positively correlated with duration
of the disease and the relationships were statistically highly significant (p<0.01). Conclusion: The
results conclude that sympathetic reflex response was reduced in RA which was deteriorated with
duration of disease.
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Keywords
RA, sympathetic reactivity, hand grip test, orthostatic test
Citation
Ferdousi Sultana, Jahan Kowser, Begum Noorzahan. Relationship of Sympathetic Dysfunction with Disease Duration In Female Rheumatoid Arthritis Patients. Journal of Bangladesh Society of Physiologists. 2015 June; 10(1):17-20.