Effect of Peanut (Arachis Hypogaea L.) On Fasting Blood Glucose And Hba1c in Alloxan Induced Diabetic Male Rats.
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Date
2014-12
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Abstract
Background: Diabetes mellitus (DM) is a heterogeneous group of metabolic disorders with micro and
macrovascular complications which are the major causes of morbidity and mortality in diabetic patients.
Peanut due to its anti-oxidant property can reduce blood glucose level and may reduce the risk of
diabetes. Objective: To observe the anti-diabetic effects of peanut (Arachis hypogaea L.) in alloxaninduced
diabetic male rats. Method: This experimental study was carried out in the Department of
Physiology, Sir Salimullah Medical College (SSMC), Dhaka in 2013. For this purpose, 15 wistar albino
male rats, aged 90-120 days, weighing 160-200 g (initial body weight) were included in the experimental
group (DG-A-P). Age and weight matched 20 wistar albino rats without peanut supplementation was
taken as control and divided into (BC and DC-A) . All groups of animals received basal diet for 21
consecutive days. In addition to basal diet, animals of DC-A received alloxan intraperitoneally only on
the first day of the study. Moreover, animals of DG-A-P also received peanut extract for 21 consecutive
days. After 16 hours of fasting blood samples were collected from tail vein of all rats on day-1 and day-
3. After taking final body weight all the rats were sacrificed on 22nd day. Their pancreas was removed
and weighed. To observe glycemic control serum blood glucose and blood HbA1c levels were measured
by usual laboratory technique. ANOVA, independent t-test and paired t-test were used for statistical
analysis. Result: The % change of body weight was significantly (p<0.001) lower in DC-A in comparison
to that of BC. The weight of pancreas was significantly lower in DC-A (p<0.001) and DG-A-P (p<0.05)
when compared to that BC, whereas this level was significantly higher (p<0.001) in DG-A-P than that
of DC-A. The mean fasting blood glucose level on day-3 was significantly (p<0.001) higher in DC-A
and DG-A-P in comparison to that of BC. Then this level was significantly (p<0.001) lower in DG-A-P
in comparison to that of DC-A on day-22. Moreover, significantly higher levels of HbA1c were
observed in DC-A (p<0.001) and DG-A-P (p<0.05) in comparison to those of BC. Again, significantly
(p<0.001) lower level of blood HbA1c were observed in DG-A-P than those of DC-A. Conclusion:
From this study, it can be concluded that peanut (Arachis hypogaea L.) has anti-diabetic effect by
reducing fasting blood glucose, HbA1c levels. This anti-diabetic effect may be due to its high MUFA
content and anti-oxidant property.
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Keywords
Anti-diabetic, Peanut, Alloxan
Citation
Akter Fatema, Jahan Nasim, Sultana Nayma. Effect of Peanut (Arachis Hypogaea L.) On Fasting Blood Glucose And Hba1c in Alloxan Induced Diabetic Male Rats. Journal of Bangladesh Society of Physiologists. 2014 Dec; 9(2): 48-53.