Assessment of Coagulation Disorder in Women Taking Oral Contraceptives.
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Date
2014-06
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Abstract
Background: Oral contraceptive pill (OCP) is related to development of hypercoagulability and the
risk of thromboembolic effects in women. Objectives: To assess the coagulability status in women
taking oral contraceptives by estimation of plasma fibrinogen level and total count of platelets.
Methods: This cross sectional study was conducted in the Department of Physiology, Dhaka Medical
College, Dhaka, during the period of January 2012 to December 2012 on sixty apparently healthy
female subjects aged 25 to 45 years taking OCPs
for 1 to 10 years. Thirty subjects were 1 to 5 years
user group and another 30 subjects were >5 to 10 years user group. They were collected from family
planning clinics of Dhaka city. In addition, age matched 30 apparently healthy women of OCP nonusers
were also studied as control. For assessment of coagulability state, plasma fibrinogen and total
counts of platelet levels were estimated by automated coagulation analyzer and automated hematology
analyzer. Statistical analysis was done by unpaired Student’s t’ test. Results: The mean (±SE) total
count of platelet level was significantly higher (P<0.001) in contraceptive user group and plasma
fibrinogen level was higher in users but it was not significant. Conclusion: This study concludes that
OCP users had more tendency of hypercoagulability and therefore these women are at higher risk of
thromboembolic effects.
Description
Keywords
Oral Contraceptives, Hypercoagulability, Plasma fibrinogen, Total counts of platelet
Citation
Samsunnahar, Akhter Qazi Shamima, - Atiquzzaman, Akhter Najneen, Begum US Naima, Rahman Farhana. Assessment of Coagulation Disorder in Women Taking Oral Contraceptives. Journal of Bangladesh Society of Physiologists. 2014 June; 9(1): 1-5.