Histomorphometric Changes of The Parietal Cell of The Stomach with Age - A Postmortem Study.
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Date
2013-12
Authors
Begum, Gul Newaz
Nurunnabi, Abu Sadat Mohammad
Shahriah, Sunjida
Rayhan, Khandaker Abu
Begum, Mahamuda
Journal Title
Journal ISSN
Volume Title
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Abstract
Background: The quantity of acid produced by the stomach correlates with the functional capability
and number of parietal cell mass. Researchers have found that the number of parietal cells tends to
increase with advancing age in different population-based studies. Objective: A cross-sectional
descriptive type of study was designed to see the variation in the number and diameter of the parietal
cells of the stomach with advancing age in Bangladeshi people. Methods: The present study was
done in the Department of Anatomy, Dhaka Medical College, Dhaka, from July 2005 to June 2006,
based on collection of 60 human stomachs from the unclaimed dead bodies that were under examination
in the morgue of Dhaka Medical College, Dhaka. The samples were divided into three age-groups
including group A (2-16 years), group B (17-22 years) and group C (23-65 years). A total of 8 relatively
fresh samples from group A, 8 from group B and 14 from group C were selected for histological study.
Then best prepared histological slides from each group were taken and examined under the light
compound microscope to determine the number per sq. mm and average diameter of the parietal cells
by using the ocular micrometer. Results: The number of parietal cells per square mm of microscopic
fields were found 1197.88±73.34 in group A, 1362.25±55.67 in group B and 1615.57±123.57 in group C.
The difference between group A & B, B & C and A & C were statistically significant. The average
diameter of the parietal cells were found 14.44±1.58ìm, 16.87±0.48ìm, 17.67±1.28ìm in group A, B and C
respectively. The difference between group A & B and A & C were statistically significant. Conclusion:
The number of the parietal cells increases with age, even in old age. However, the diameter of the
parietal cell increases up to the 3rd decade of life and then remains static.
Description
Keywords
Stomach, histology, gastric gland, parietal cell
Citation
Begum Gul Newaz, Nurunnabi Abu Sadat Mohammad, Shahriah Sunjida, Rayhan Khandaker Abu,Begum Mahamuda. Histomorphometric Changes of The Parietal Cell of The Stomach with Age - A Postmortem Study. Journal of Bangladesh Society of Physiologists. 2013 Dec; 8(2): 89-93.