Micronutrient Deficiency in Severe Preeclampsia.
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Date
2013-06
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Abstract
Background:. Micronutrient such as calcium, magnesium and zinc deficiency are associated with
preeclampsia. Objective: To observe serum calcium, magnesium and zinc levels in severe preeclamptic
women. Methods: This cross sectional study was carried out in the Department of Physiology,
Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka from July 2009 to June 2010. 60
cases of preeclampsia, aged 18-39 years and >20th weeks of pregnancy were included in the study
group. They were further sub divided into group B1 (30 mild preeclampsia) and group B2 (30 severe
preeclampsia). Age and gestational period matched 30 normotensive pregnant women (Group A)
were also studied as control. All the preeclamptic women were selected from the Obstetric and
Gynaecology in and out patient Department of BSMMU and Dhaka Medical College Hospital.
Serum calcium and magnesium was measured by colorimetric and serum zinc was measured by
spectrophotometric method. For statistical analysis one way ANOVA, independent sample t test
and รท2 test were used. Results: The mean serum calcium, magnesium and zinc levels were
significantly (p<0.001) lower in both group of preeclampsia than normotensive pregnant women.
Again serum calcium and zinc levels were significantly lower (P<0.05) in severe preeclampsia
compared to mild preeclampsia whereas serum magnesium levels were found almost similar in both
group of preeclampsia (P>0.05). Again in this study, 40% mild, 73.3 % severe preeclamptic women
and 20% normotensive pregnant women had hypocalcaemia. 36.7% mild, 30.0% severe preeclamptic
women and 3.3% normotensive pregnant women had hypomagnesaemia and 6.7% mild, 20 % severe
preeclamptic women and no normotensive pregnant women had hypozincemia. Conclusion: This
study may conclude that micronutrient deficiency may be one of the risk factor of preeclampsia and
increases the risk of its severity. Therefore early detection and supplementation to treat this deficiency
may reduce the incidence of preeclampsia.
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Keywords
Calcium, magnesium, Zinc, preeclamptic women
Citation
Akhter Selina, Ali Taskina, Begum Shelina, Ferdousi Sultana. Micronutrient Deficiency in Severe Preeclampsia. Journal of Bangladesh Society of Physiologists. 2013 June; 8(1): 26-32.