PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c.
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Date
2013-06
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Abstract
Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to
microvascular, macrovascular and neuropathic diseases which affect eyes, kidneys, heart, blood
vessels and also lungs. So, there may be a relationship between type-1 diabetes and reduced lung
function. Objectives: To observe PEFR, FEF25-75 and MVV and their relationship with HbA1c in type-
1 diabetic male in Bangladesh. Methods: This cross-sectional study was carried out in the Department
of Physiology, Sir Salimullah Medical College, Dhaka between 1st January and 31st December 2009. A
total 30 type-1 diabetic male subjects, age 18-30 years were taken as study group. Another 30 apparently
healthy age, sex, BMI and socioeconomic status matched non-diabetic persons were also included as
control. For assessment of lung function PEFR, FEF25-75 and MVV of all the subjects were measured
by a digital spirometer. Again, to observe glycemic control serum blood glucose and glycosylated
hemoglobin (HbA1c) levels of diabetic patients were also measured by usual laboratory technique.
Data were analyzed by unpaired‘t’ test and Pearson’s correlation coefficient test. Results: PEFR
(p<0.001), FEF25-75 (p<0.001), and MVV (p <0.001) were significantly lower in type-1 diabetic patients
in comparison to those of apparently healthy non-diabetic male. Again, their PEFR (p < 0.05), FEF25-75
(p>0.05), and MVV (p<0.05) were negatively correlated with HbA1c. Conclusion: The lung functions
were lower in type-1 diabetic male in comparison to those of non-diabetic counterpart and this reduction
is mainly due to poor glycemic control.
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Keywords
Type-I diabetes mellitus, Lung function parameters, Glycosylated hemoglobin
Citation
Arif Khan Mohammad, Jahan Nasim, Sultana Nayma. PEFR, FEF25-75 and MVV In Type-1 Diabetic Male And Their Relationships With HbA1c. Journal of Bangladesh Society of Physiologists. 2013 June; 8(1): 16-20.