Short-term Ibuprofen Treatment and Pulmonary Function in Children with Asthma.
Loading...
Date
2015-08
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: To investigate the association between ibuprofen use and pulmonary function in
children with Asthma.
Methods: Ninety 9- to 10-year-old children were classified into 3 groups: Study group, mild to
moderate stable asthmatic children with self-reported aspirin allergy and no history of
anaphylaxis; Allergy control group: atopic children (allergic rhinitis/atopic dermatitis); Healthy
control group: non-atopic healthy children. None of the participants in the atopic and healthy
control groups had a history of aspirin allergy. All received ibuprofen 4 times a day for 3
consecutive days. Forced expiratory volume in the first second (FeV1) and fractional exhaled
nitric oxide (FeNO) measurements were performed before and after ingestion of ibuprofen
daily for 3 days.
Results: In the study group, a decrease in FeV1 and increase in FeNO levels were observed
after taking ibuprofen for 2 days. The atopic control group showed only an increase in FeNO
but not FEV1. In the healthy control group, both FeV1 and FeNO were unchanged from
baseline.
Conclusions: The results showed that cross-reactive non-steroidal anti-inflammatory drug
hypersensitivity may exist between ibuprofen and aspirin. This raises the possibility that
asthma exacerbation could be mediated by ibuprofen ingestion.
Description
Keywords
Asthma, Exhaled nitric oxide, FeV1, Ibuprofen, NSAID
Citation
Su Yu-Mao, Huang Che-Sheng, Wan Kong-Sang. Short-term Ibuprofen Treatment and Pulmonary Function in Children with Asthma. Indian Pediatrics. 2015 Aug; 52(8): 691-693.