Long-term Immunogenicity of Single Dose of Live Attenuated Hepatitis A Vaccine in Indian Children.
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Date
2015-08
Journal Title
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Abstract
Objectives: To assess immunogenicity of a single dose of live attenuated hepatitis A vaccine
in Indian children, ten years after immunization.
Methods: Of 143 children vaccinated in 2004, 121 children were evaluated in 2014, clinically
and for anti-HAV antibodies.
Results: 13 children were early vaccine failures who received two doses of HAV vaccine
subsequently. 106 (98%) of 108 remaining children had seroprotective levels with a
geometric mean titer of 100.5 mIU/mL. On analysis of all 121 children, the immunogenicity
was 87.6%.
Conclusion: Single dose of live attenuated hepatitis A vaccine provides long-term immunity
in Indian children.
Description
Keywords
Immunization, Prevention, Protection, Hepatitis A vaccine
Citation
Bhave Sheila, Sapru Amita, Bavdekar Ashish, Kapatkar Vaibhavi, Mane Amey. Long-term Immunogenicity of Single Dose of Live Attenuated Hepatitis A Vaccine in Indian Children. Indian Pediatrics. 2015 Aug; 52(8): 687-690.