FVC, FEV1 And FEV1/FVC% In Type-1 Diabetic Male And Their Relationships With HbA1c.
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Date
2012-06
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Abstract
Background: Diabetes mellitus is a chronic and debilitating disease. Its complications give rise to
micro and macrovascular diseases which affect eyes, kidneys, heart, blood vessels, nerves and also
lungs. There may be a relationship between type-1 diabetes and reduced lung function. Objectives:
To observe FVC, FEV1, FEV1/FVC % and their relationship with HbA1C in type-1 diabetic male in
Bangladesh. Methods: This cross-sectional study was carried out in the Department of Physiology,
Sir Salimullah Medical College, Dhaka from January to December 2009. A total number of 60 male
subjects, from 18-30 years of age was taken and was divided into control and study groups. Among
them study group was consisted of 30 type-1 diabetic male patients. Control group was consisted of
30 apparently healthy age, sex, BMI and socioeconomic status matched non-diabetic subjects. All the
subjects belonged to lower socio-economic status. For assessment of lung function, FVC, FEV1,
FEV1/FVC % of all the subjects were measured. All of theses tests were done by spirometric method
by using a digital Spirometer. Again, to observe glycemic control of blood, glycosylated hemoglobin
(HbA1c) levels of diabetic patients were also measured by usual laboratory technique. Data were
analyzed by Independent-Samples ‘t’ test and Pearson’s correlation coefficient test as applicable.
Results: FVC (p <0.001), FEV1 (p < 0.001), and FEV1/FVC% (p < 0.05) were significantly lower in type-
1 diabetic patients in comparison to those of apparently healthy non-diabetic male. Again FVC and
FEV1 had significant (p < 0.001) negative correlation but FEV1/FVC% had non-significant positive
correlation with HbA1c. Conclusion: Impairment of some lung functions may be found in type-1
diabetic male which may be due to poor glycemic control.
Description
Keywords
Type-I diabetes mellitus, Lung function parameters, Glycosylated hemoglobin
Citation
Arif Khan Mohammad, Jahan Nasim, Sultana Nayma, Akter Rezina. FVC, FEV1 And FEV1/FVC% In Type-1 Diabetic Male And Their Relationships With HbA1c. Journal of Bangladesh Society of Physiologists. 2012 June; 7(1): 23-28.