Analysis of Efficacy & Safety of Inhaled Tiotropium and Tiotropium Plus Formoterol in COPD.
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Date
2010-01
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Abstract
A randomized, open labeled comparative analysis for 2-week therapy of inhaled Tiotropium (T) (n=30) and
Tiotropium plus Formoterol (TF) (n=30) once daily was carried in stable COPD patients. Objective
parameters like lung functions (FEV1 and FVC), SBP, DBP, pulse and subjective parameters like
improvement in respiratory symptoms & safety were assessed at baseline and after 2 weeks of treatment.
Mean FEV1 was 1.0963±0.3826 & 1.1657±0.3701 as well as 1.1227±0.4129 & 1.2260±0.3830 before &
after treatment with inhaled T & TF respectively. A statistically significant p<0.05 and p<0.001 improvement
was only observed for FEV1 without significantly affecting other study parameters with two treatment
modalities respectively when analyzed from respective base lines. However, on comparing the post drug
improvement in objective & subjective parameters among T & TF treatment arms showed statistically
insignificant p>0.05 variation. Both the regimens were well tolerated and no case warranted withdrawal of
treatment. The present study suggests that in the treatment of COPD, inhaled long acting bronchodilators
(T & TF) on comparison appear equally effective & safe.
Description
Keywords
COPD, Tiotropium, Formoterol, Bronchodilators, Lung Function
Citation
Pukhta Muzaffer Ahmad, Ashai Zubair Ahmad, Shah Mushtaq Ahmad, Abbas Zaffar, Farhat Samina, Mir Shakeel Ahmad, Singh Z, Tandon Vishal R. Analysis of Efficacy & Safety of Inhaled Tiotropium and Tiotropium Plus Formoterol in COPD.JK Science Journal of Medical Education and Research. 2010 Jan-Mar; 12(1): 27-30