Studies on Serum Creatinine and Creatinine Clearance in Hypertensive Patients.
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Date
2006-12
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Abstract
Objectives: To assess the serum creatinine and creatinine clearance values in hypertensive patients
for providing information to the health-policy planners, clinical practitioners about the importance of
routine monitoring of serum creatinine and creatinine clearance in hypertensive patients for prevention
of ESRD and other consequences to combat morbidity and mortality and to reinforce the need to
consider these parameters in daily clinical practice. Study design: It was a cross-sectional study.
Setting: The study was conducted at Department of Physiology and Biochemistry of Mymensingh
Medical College, Medicine Unit of Mymensingh Medical College Hospital. Study period: The period
of the study was January 2005 to December 2005. Participants: A total number of seventy subjects
were included in this study. Out of 70 subjects, 40 (forty) were hypertensive patients and 30 (thirty)
were normotensive & healthy controls. Intervention: The subjects were selected on the basis of
history and clinical examination. Convenient sampling technique was applied. During visit the available
hypertensive patients and controls (normotensive & healthy) those who were present were selected.
Having received their written consent they were interviewed & examined by prepared personal data
sheet and sample of blood (after overnight fasting) was drawn for biochemical examination. Main
outcome measure: Mean values of serum creatinine and creatinine clearance. Result: Serum creatinine
was greater in hypertensive than those of normotensive. Creatinine clearance was less in hypertensive
than those of normotensive. Serum creatinine & creatinine clearance in between males hypertensive
& control shows that CrCl were statistically significant but not the serum creatinine. In females of
hypertensive & control shows no differences in case of SCr & CrCl. Among 40 hypertensive the
number of “Getting treatment - regular” & “ Getting treatment-irregular” was 14 (35%) & 26 (65%)
respectively. Similarly in patients “suffering less than 5 yrs” and “suffering 5 yrs & above” the
differences are also not statistically significant. Conclusion: The observations of this study revealed
that most of the hypertensive patients were taking treatment irregularly and there was significant
alteration of biochemical parameters in hypertensive patients. Therefore, for routine monitoring of
hypertensive patients to prevent the end stage renal disease (ESRD) and other consequences, the
reinforcement of the investigations of these parameters may be recommended in daily clinical practice.
Description
Keywords
Hypertension, creatinine, creatinine clearance, Cockcroft-Gault formula
Citation
Sarkar D, Latif S A, Aich J, Uddin M M. Studies on Serum Creatinine and Creatinine Clearance in Hypertensive Patients. Journal of Bangladesh Society of Physiologists. 2006 Dec; 1(1): 19-26.