Predictors of Myocardial Dysfunction in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation.
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Date
2015-04
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Abstract
Objectives: To identify predictive risk factors for myocardial
dysfunction in children with scorpion sting envenomation and to
evaluate the effects of Scorpion antivenom and prazosin
combination therapy on occurrence of myocardial dysfunction.
Design: Observational.
Setting: Tertiary care hospital in Southern India.
Participants: 85 children aged <13 years with scorpion sting
envenomation.
Outcome measures: Frequency of myocardial dysfunction;
predictors of myocardial dysfunction.
Results: 24 children (28.2%) developed myocardial dysfunction.
Hypotension at admission (P=0.003) and increased time (>4h)
between sting and administration of appropriate therapy
(P=0.001) were independent predictors of myocardial dysfunction
on logistic regression. Scorpion antivenom plus prazosin
combination therapy led to an increase in cumulative proportion of
children without myocardial dysfunction.
Conclusion: Early (<4 hours) administration of Scorpion
antivenom along with prazosin increases the cumulative
percentage of children not developing myocardial dysfunction.
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Keywords
Children, Myocardial dysfunction, Scorpion sting envenomation, Scorpion antivenom
Citation
Kumar PM Ananda, Krishnamurthy Sriram, Srinivasaraghavan Rangan, Mahadevan Subramanian, Harichandrakumar K T. Predictors of Myocardial Dysfunction in Children with Indian Red Scorpion (Mesobuthus tamulus) Sting Envenomation. Indian Pediatrics. 2015 Apr; 52(4): 297-301.