A Randomised Comparison of Oral and Vaginal Misoprostol for Medical Management of First Trimester Missed Abortion
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Date
2006-01
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Abstract
The present study was done to compare the safety and efficacy of misoprostol administered orally and
vaginally for medical management of first trimester missed abortion. 100 women with diagnosed missed
abortion were taken for this prospective study. Group A comprised of 50 women who were given oral
misoprostol and another 50 in-group B were administered vaginal misoprostol. Clinical outcome, time
taken for expulsion, number of doses required, side effects and cervical permeability were compared in
two groups. Eighty percent in group B and 36% in group A had successful clinical outcome (p=0.000008).
16.6% in group A and 22.5% in group B expelled with a single dose while 50% and 77.5% expelled with
complete schedule. Mean duration of expulsion was significantly higher in group A as compared to group
B. Nearly ninety percent of women in both groups had good cervical permeability. Side effects were more
common in group A. Hence vaginal misoprostol was found to be more effective and safer as compared to
oral misoprostol.
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Keywords
Misoprostol, First Trimester, Missed Abortion
Citation
Rita, Gupta Shashi, Kumar Surender. A Randomised Comparison of Oral and Vaginal Misoprostol for Medical Management of First Trimester Missed Abortion. JK Science Journal of Medical Education and Research. 2006 Jan-Mar;8(1): 35-38