Status of Vitamin C and Vitamin E in Acute Pancreatitis and their Prognostic Significance
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Date
2005-10
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Abstract
Experimental and clinical studies have provided some support for the concept that oxidative stress is
the common pathway for initiation of acute pancreatitis. Ascorbic acid (vitamin C) and alpha
tocopherols (vitamin E) are the key anti- oxidants in human blood plasma. In present study our aims
was to measure the levels of Vitamin-C & Vitamin-E (Alpha- Tocopherol) in patients of acute
pancreatitis and to compare the levels with control group as well as to assess the prognostic significance
of Vitamin-C & Vitamin-E levels in acute pancreatitis in relation to Ranson’s criteria. Serum levels of
vitamin C & E were measured in 50 cases having acute pancreatitis and 20 controls having pain
abdomen of non pancreatic origin. Levels of vitamin C and vitamin E were compared with the
controls and were correlated to the severity of disease according to Ranson’s criteria. The difference
in the levels of vitamin C between the study group and the control group was statistically nonsignificant
at the time of admission and at 48 hours. However the difference was statistically significant
at 7 days. The difference in the levels of vitamin E between the study group at the admission is
statistically non-significant when compared to the levels in the control group at the time of admission,
at 48 hours and at 7 days after the admission. No correlation was found between the levels of vitamin
C and vitamin E at the time of admission, at 48 hours and at 7 days with the severity of disease
according to Ranson’s score. There is an initial fall in the levels of vitamin C with the rising trend
towards the end of the 7 days period. The levels of the vitamin E had rising trend towards the end of
the 7 days but no statistically significant initial fall in the levels as compared to the control group.
Levels of vitamin C and vitamin E have no prognostic significance in the cases of acute pancreatitis.
Description
Keywords
Acute Pancreatitis, Vitamin C, Vitamin E
Citation
Ohri Ashish, Goyal Subhash, Narang APS, Multani Jangpreet Singh, Vij B. Status of Vitamin C and Vitamin E in Acute Pancreatitis and their Prognostic Significance. JK Science Journal of Medical Education and Research. 2005 Oct-Dec;7(4): 216-219