Effects of Exogenous Ethinyl Estradiol on Endometrial Receptivity in Clomiphene Induced Cycles in Infertile Women with Polycystic Ovaries
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Date
2005-07
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Abstract
To compare the effectiveness of clomiphene citrate used alone and in combination with ethinyl
estradiol on endometrial receptivity in infertile women with polycystic ovaries (PCO). Color doppler
ultrasonographic evaluation of endometrial thickness (ET) and pulsatility index (PI) was done for 27
infertile women with polycystic ovaries. These women were studied for one control unmedicated
cycle and randomized to receive clomiphene citrate (CC) alone and CC with ethinyl estradiol (EE) in
subsequent 2 cycles. The total duration of follow up of patients was 77 months in which 2 women
conceived in control cycle and 1 conceived in CC+ EE cycle. On day of HCGinjection, mean ET was
6.96 + 1.63mmin control cycle, 7.25 + 1.64mmin CC and 8.53 + 1.36mmin CC + EE cycle, whereas,
the mean pulsatility index (PI) of dominant uterine arteries was 4.09 + 0.97 in control cycle, 3.96 + 0.95 in
CC cycle and 3.75 + 0.98 in CC + EE cycle. On day of HCG injection, mean PI of non-dominant uterine
arteries was 4.06 + 1.01 in control, 4.00 + 1.02 in CC and 3.71 + 0.95 in CC + EE cycles. A statistically
significant change (p< 0.05) was observed in ET and PI of dominant and non-dominant uterine arteries in
control and CC+ EE cycle and those in CC and CC+ EE cycles. Addition of ethinyl estradiol to clomiphene
induced cycles produces a favorable endometrial response in infertile women with PCO.
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Keywords
Polycystic ovaries (PCO), Color Doppler, Endometrial thickness (ET), Pulsatility index (PI)
Citation
Swasti, Khanna S B, Kaul U. Effects of Exogenous Ethinyl Estradiol on Endometrial Receptivity in Clomiphene Induced Cycles in Infertile Women with Polycystic Ovaries. JK Science Journal of Medical Education and Research. 2005 Jul-Sept;7(3): 140-145