Intravaginal Misoprostol Versus Intra-amniotic 15 Methyl PG F2α for Termination of Second Trimester Pregnancy
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Date
2005-01
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Abstract
To compare the efficacy of intravaginal application of misoprostol and intra-amniotic injection of
prostaglandin 15-methyl F2 alpha (PG F2α) in terminating second trimester pregnancies, eighty
pregnant women at 14-20 weeks of gestation with single live fetuses and requesting for termination
of pregnancy were randomised into two groups.Women in group I: received four tablets of vaginal
misoprostol (200 mg/tablet) and in group II : intra-amniotic injection of (10 ml) 2.5 mg 15 methyl -
PGF2α. Failure to abort within 48 hours after intiation of treatment occurred in one woman (2.5%)
in the misoprostol group and 10 women (25%) in the 15 methyl PGF2α group (P = 0.009). Mean
induction-to-abortion interval was 16.3±13 hr in the misoprostol group and 21.2±16 hr in the 15
methyl PGF2a group (P=.001). Lower abdominal pain was significantly higher in the misoprostol
group than in the 15 methyl PGF2α group (P = 0.001). Intravaginal misoprostol in a dose of 800mg is
more effective than intra-amniotic 15-methyl PGF2α for second trimester pregnancy termination.
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Keywords
Second trimester abortion, Misoprostol, Prostaglandins
Citation
Vimala N, Dadhwal V, Kumar S, Mittal S, Vinekar S. Intravaginal Misoprostol Versus Intra-amniotic 15 Methyl PG F2α for Termination of Second Trimester Pregnancy. JK Science Journal of Medical Education and Research. 2005 Jan-Mar;7(1): 1-3