Serum IgG and IgA Levels in Polio and Non-polio Acute Flaccid Paralysis Cases in Western Uttar Pradesh, India.
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Date
2015-03
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Abstract
Objective: IgG and IgA immunocompetence of children with wild poliovirus poliomyelitis and
non-polio acute flaccid paralysis.
Methods: 932 cases of acute flaccid paralysis, reported in 2008-2009, were tested for
presence of polio and non-polio enteroviruses according to the WHO standards. Serum IgA
and IgG levels were determined by sandwich ELISA.
Results: Mean (SD) IgA levels [0.87 (0.62)g/L; n=28] of virologically confirmed poliomyelitis
cases were lower than those of virus negative [1.21 (0.83)g/L; n=612] and non-polio
Enterovirus positive [1.22 (0.79)g/L; n=240] cases of acute flaccid paralysis. No significant
difference was observed in the concentration of IgG among these groups.
Conclusion: IgA plays an important role in protection against poliomyelitis.
Description
Keywords
Acute flaccid paralysis, Poliovirus, Poliomyelitis, Serum immunoglobulins
Citation
Mohanty Madhu C, Nalavade Uma P, Deshpande Jagadish M. Serum IgG and IgA Levels in Polio and Non-polio Acute Flaccid Paralysis Cases in Western Uttar Pradesh, India. Indian Pediatrics. 2015 Mar; 52(3): 220-222.