Immunofluorescence profile of discoid lupus erythematosus.
Date
2015-10
Journal Title
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Abstract
The direct immunofluorescence (DIF) of skin in conjunction with histopathology
gives the best diagnostic yield. It is invaluable in confirming the diagnosis of
small vessel vasculitides and bullous lesions of the skin and can be used as an
additional tool to pinpoint the diagnosis of systemic and localized autoimmune
diseases involving the skin. This study was undertaken to analyze the strength of
DIF vis‑à‑vis histopathology in the diagnosis of discoid lupus erythematosus (DLE)
and at the same time to elaborate the specific immunofluorescence findings in
the lesions of DLE. The clinical profile and cutaneous lesions of 75 patients with
DLE are described. DIF was positive in 68% and histopathology in 60% of cases.
The most common immunoreactant was IgG at the dermoepidermal junction,
followed by IgM and IgA. A conclusive diagnosis of DLE could be achieved
satisfactorily in 64 cases (85%) by a combination of the two techniques.
Description
Keywords
Direct immunofluorescence, discoid lupus erythematosus, skin
Citation
Bharti Shreekant, Dogra Sunil, Saikia Biman, Walker Ranjana Minz, Chhabra Seema, Saikia Uma Nahar. Immunofluorescence profile of discoid lupus erythematosus. Indian Journal of Pathology & Microbiology. 2015 Oct-Dec 58(4): 479-482.