Clear cell renal cell carcinoma with hemangioblastomalike features: A recently described pattern with unusual immunohistochemical profile.
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Date
2015-07
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Abstract
The diagnosis of clear cell renal cell carcinoma may sometimes pose challenges
because of the presence of uncharacteristic morphology, varied immunophenotypic
patterns and due to lack of molecular or genetic determinants. More often, the
morphological variations can be easily overlooked in routine practice and a more
common diagnosis is usually put forward. Solid, acinar and alveolar are the common
patterns described in the literature. We report a recently described pattern of clear cell
renal cell carcinoma which has hemangioblastoma-like morphology and an unusual
immunoprofi le. In our case, the tumor showed a diffuse hemangioblastoma-like pattern
and diffuse positivity for Alpha-inhibin on immunohistochemistry. A thorough literature
search, extensive sampling and an expanded immunohistochemistry panel revealed
a clear cell renal cell carcinoma component. Presence of renal vein thrombosis and
focal necrosis were other helpful features in discerning the malignant nature of tumor.
Description
Keywords
Clear cell renal cell carcinoma, hemangioblastoma, Alpha-inhibin
Citation
Sancheti Sankalp, Menon Santosh, Mukherjee Satyadip, Arun Indu. Clear cell renal cell carcinoma with hemangioblastomalike features: A recently described pattern with unusual immunohistochemical profile. Indian Journal of Pathology & Microbiology. 2015 Jul-Sept 58(3): 354-355.