The role of central reading centers – current practices and future directions.
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Date
2015-05
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Abstract
Central reading centers (CRCs) have several crucial roles in the conduct of clinical trials, providing key
input during the study design, preparation of the operations manual, as well as site and photographer
certification. They provide objective, standardized grading of images from study subjects, which determines
study eligibility, and also evaluate lesion features at subsequent study visits. CRCs need to adhere strictly to
Good Clinical Practice (GCP) guidelines, as well as the established standard operating procedures in order
to ensure that images are graded properly. The role of CRCs will continue to evolve, and include the use of
web‑based image transmission and grading platforms.
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Keywords
Central reading center, randomized controlled trial, standard operating procedure
Citation
Tan Colin S, Sadda Srinivas R. The role of central reading centers – current practices and future directions. Indian Journal of Ophthalmology. 2015 May; 63(5): 404-405.