En-face optical coherence tomography in the diagnosis and management of age-related macular degeneration and polypoidal choroidal vasculopathy.
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Date
2015-05
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Abstract
Optical coherence tomography (OCT) is a noninvasive imaging modality providing high‑resolution images
of the central retina that has completely transformed the field of ophthalmology. While traditional OCT has
produced longitudinal cross‑sectional images, advancements in data processing have led to the development
of en‑face OCT, which produces transverse images of retinal and choroidal layers at any specified depth.
This offers additional benefit on top of longitudinal cross‑sections because it provides an extensive overview
of pathological structures in a single image. The aim of this review was to discuss the utility of en‑face OCT
in the diagnosis and management of age‑related macular degeneration (AMD) and polypoidal choroidal
vasculopathy (PCV). En‑face imaging of the inner segment/outer segment junction of retinal photoreceptors
has been shown to be a useful indicator of visual acuity and a predictor of the extent of progression
of geographic atrophy. En‑face OCT has also enabled high‑resolution analysis and quantification of
pathological structures such as reticular pseudodrusen (RPD) and choroidal neovascularization, which
have the potential to become useful markers for disease monitoring. En‑face Doppler OCT enables subtle
changes in the choroidal vasculature to be detected in eyes with RPD and AMD, which has significantly
advanced our understanding of their pathogenesis. En‑face Doppler OCT has also been shown to be useful
for detecting the polypoid lesions and branching vascular networks diagnostic of PCV. It may therefore
serve as a noninvasive alternative to fluorescein and indocyanine green angiography for the diagnosis of
PCV and other forms of the exudative macular disease.
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Keywords
Age‑related macular degeneration, en‑face optical coherence tomography, polypoidal choroidal vasculopathy
Citation
Lau Tiffany, Wong Ian Y, Iu Lawrence, Chhablani Jay, Yong Tao, Hideki Koizumi, Lee Jacky, Wong Raymond. En-face optical coherence tomography in the diagnosis and management of age-related macular degeneration and polypoidal choroidal vasculopathy. Indian Journal of Ophthalmology. 2015 May; 63(5): 378-383.