Outcome of Very Low Birth Weight Infants with Abnormal Antenatal Doppler Flow Patterns: A Prospective Cohort Study.
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Date
2013-09
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Abstract
Background: Fetal growth restriction and abnormal Doppler flow
studies are commonly associated. Neonatal outcomes are not
well known particularly in developing countries, where the burden
of the disease is the highest.
Objective: To determine outcomes of preterm infants with history
of absent/reversed end-diastolic umbilical artery Doppler flow
(AREDF) vs. infants with forward end-diastolic flow (FEDF).
Design: Cohort study.
Setting: Tertiary care perinatal center in India.
Participants: 103 AREDF very low birth weight (<1500 gm)
(VLBW) infants and 117 FEDF VLBW infants were prospectively
enrolled.
Results: At 40 weeks adjusted post-menstrual age, AREDF vs.
FEDF group had a higher risk for death in the NICU (12% vs. 1%),
respiratory distress syndrome (33% vs. 19%), and cystic
periventricular leukomalacia (12% vs. 1%). At 12-18 months
corrected age, AREDF vs. FEDF group had a trend towards
increased risk for cerebral palsy (7% vs. 1%, P=0.06). After
logistic regression analysis, adjusting for confounders, AREDF
was independently associated only with mortality in the NICU.
Conclusion: AREDF is an independent predictor of adverse
outcomes in preterm infants in a developing country setting.
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Keywords
India, Intrauterine growth restriction, Outcome, Pre-eclampsia., Prognosis
Citation
Lakshmi C V S, Pramod G, Geeta K, Subramaniam S, Rao Marepalli B, Kallapur Suhas G, Murki S. Outcome of Very Low Birth Weight Infants with Abnormal Antenatal Doppler Flow Patterns: A Prospective Cohort Study. Indian Pediatrics. 2013 September; 50(9): 847- 852.