Serum Vascular Endothelial Growth Factor-A Levels During Induction Therapy in Children with Acute Lymphoblastic Leukemia.
Loading...
Date
2013-07
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objective: To evaluate serum vascular endothelial growth
factor (VEGF) levels in children with acute lymphoblastic
leukemia (ALL) during the induction phase of chemotherapy.
Design: Prospective sudy.
Setting: Hospital-based study over 18 months.
Patients: 30 children with ALL and 17 healthy age- and sexmatched
controls.
Intervention: Serum concentration of VEGF-A–165 isoform (s-
VEGF) was measured by enzyme-linked immunoabsorbant
assay at diagnosis and at the end of induction chemotherapy.
Main outcome measures: s-VEGF was compared with
markers of tumor burden. Kinetics of s-VEGF was assessed in
response to induction chemotherapy.
Results: Median VEGF was significantly lower in untreated
patients than in controls (17.0 vs. 42.6 pg/mL, P=0.004). s-VEGF
levels were fairly correlated with WBC count (r=-0.56, P=0.004)
and LDH (r=-0.52, P=0.02) at diagnosis. All patients but one were
in morphologic remission at the end of induction. Median s-VEGF
concentration on day 29/33 was significantly higher than on day
1 (44.2 pg/mL, P=0.009).
Conclusion: Untreated children with ALL have significantly
lower s-VEGF concentration than controls. At the end of the
induction therapy, s-VEGF increased to levels similar to controls.
The role of ligand-receptor interaction between VEGF and VEGF
receptors on leukemia cells needs to be further delineated.
Description
Keywords
Angiogenesis, hematological malignancy, VEGF
Citation
Kalra Manas, Dinand Veronique, Choudhary Sangeeta, Sachdeva Anupam, Yadav Satya Prakash. Serum Vascular Endothelial Growth Factor-A Levels During Induction Therapy in Children with Acute Lymphoblastic Leukemia. Indian Pediatrics. 2013 July; 50(7): 659-662.