Comparison of Analgesic Effect of Direct Breastfeeding, Oral 25% Dextrose Solution and Placebo during 1st DPT Vaccination in Healthy Term Infants: A Randomized, Placebo Controlled Trial.
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Date
2013-07
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Abstract
Objective: To compare analgesic effect of direct breast feeding,
25% dextrose solution and placebo as we give 1st intramuscular
whole cell DPT injection to 6week - 3month old infants.
Design: Randomized, placebo controlled trial.
Setting: Immunization clinic of Department of Pediatrics, LLRM
Medical College.
Participants: Infants coming for their 1st DPT vaccination were
randomized in to three groups of 40 each.
Outcome measures: The primary outcome variable was the
duration of cry after vaccination. Secondary outcome variables
were Modified Facial Coding Score (MFCS) and latency of onset
of cry.
Results: 120 babies were equally enrolled in breast feed group,
25% dextrose fed group and distilled water fed group. Median
(interquartile range) of duration of cry was significantly lower in
breast fed (33.5 (17-54) seconds) and 25% dextrose fed babies
(47.5 (31-67.5) seconds) as compared to babies given distilled
water (80.5 (33.5-119.5) seconds) (P<0.001). MFCS at 1 min and
3 min was significantly lower in direct breast fed and dextrose fed
babies.
Conclusions: Direct breastfeeding and 25% dextrose act as
analgesic in young infants undergoing DPT vaccination in young
infants less than 3 month of age.
Description
Keywords
25% dextrose, Breastfeeding, uration of cry, Management, DPT vaccination, Pain, Infant
Citation
Goswami Gaurav, Upadhyay Amit, Gupta Navratan Kumar, Chaudhry Rajesh, Chawla Deepak, Sreenivas V. Comparison of Analgesic Effect of Direct Breastfeeding, Oral 25% Dextrose Solution and Placebo during 1st DPT Vaccination in Healthy Term Infants: A Randomized, Placebo Controlled Trial. Indian Pediatrics. 2013 July; 50(7): 649-653.