Hematological Alterations and Thymic Function in Newborns of HIV-Infected Mothers Receiving Antiretroviral Drugs.
Loading...
Date
2013-06
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objectives: To investigate the effects of antiretroviral (ARV)
drugs on hematological parameters and thymic function in HIVuninfected
newborns of HIV-infected mothers.
Study design: Cross sectional study.
Setting: Chiang-Mai University Hospital, Chiang-Mai, Thailand.
Participants/Patients: 49 HIV-uninfected and 26 HIV-infected
pregnancies.
Methods: Cord blood samples of newborns from HIVuninfected
and HIV-infected mothers were collected.
Hematological parameters were measured using automatic
blood cell count. T-cell receptor excision circles (TRECs) levels in
cord blood mononuclear cells (CBMCs), CD4+ and CD8+ T-cells
were quantified using real-time PCR.
Main Outcome Measures: Hemotological parameters and
thymic function.
Results: Newborn of HIV-infected mother tended to have lower
mean levels of hemoglobin than those of HIV-uninfected mother
(137 ± 22 vs 146 ± 17 g/L, P = 0.05). Furthermore, mean of red
blood cell (RBC) counts and hematocrit and median of TRECs in
CD4+ T-cells in the newborns of the former were significantly
lower than those of the latter [3.6 ± 0.7 vs 4.8 ± 0.6 x 1012 cells/L,
P <0.001; 0.40 ± 0.07 vs 0.46 ± 0.05 L/L, P <0.001 and 0.53 (IQR:
0.03-5.76) vs 13.20 (IQR: 2.77-27.51) x 10-3 pg/μL, P = 0.02,
respectively].
Conclusion: ARV drugs altered hematological parameters and
thymic function (TRECs CD4+ T-cells) in HIV-uninfected
newborns of HIV-infected mothers.
Description
Keywords
Adverse effects, Antiretroviral drugs, Hematology, Newborn, HIV, Thymic function
Citation
Wongnoi Rotjanee, Penvieng Nawaporn, Singboottra Panthong, Kingkeow Doungnapa, Oberdorfer Peninnah, Sirivatanapa Pannee Pornprasert Sakorn. Hematological Alterations and Thymic Function in Newborns of HIV-Infected Mothers Receiving Antiretroviral Drugs. Indian Pediatrics. 2013 June; 50(6): 567-572.