Evaluation of the efficacy of a probiotic drink containing Lactobacillus casei on the levels of periodontopathic bacteria in periodontitis: A clinico‑microbiologic study.
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Date
2015-09
Authors
Imran, Faizuddin
Das, Sushma
Padmanabhan, Shyam
Rao, Ravi
Suresh, Aparnna
Bharath, Dhana
Journal Title
Journal ISSN
Volume Title
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Abstract
Background and Objectives: This study was designed to evaluate whether the oral administration
of lactobacilli could change the bacterial population in subgingival plaque.
Subjects and Methods: Forty‑two healthy volunteers with chronic generalized mild to moderate
periodontitis were given a probiotic drink containing Lactobacillus casei for 1 month. Subgingival
plaque samples were collected at baseline, after which the patients were asked to consume the
probiotic drink once daily for 1 month. At the 1 month interval, plaque samples were collected,
and the drink discontinued. The patients were recalled at 2 months interval for collection of
the final samples. The bacterial amounts in the plaque samples were analyzed by multiplex
polymerase chain reaction procedure.
Results: Of the three periodontopathic bacteria selected, Porphyromonas gingivalis showed highly
significant reductions in the bacterial levels at 1‑month and 2 months intervals. In comparison,
Aggregatibacter actinomycetemcomitans, when present higher than 10 × 103 at baseline, and
Prevotella intermedia present higher than 2 × 103 at baseline, showed moderately significant
reduction in their numbers.
Interpretation and Conclusion: Oral administration of the probiotic lactobacilli reduced the
numerical sum of the three selected periodontopathic bacteria and could contribute to the
beneficial effects on periodontal conditions.
Description
Keywords
Chronic Periodontitis, dental plaque, Lactobacillus casei, periodontopathic bacteria, probiotics
Citation
Imran Faizuddin, Das Sushma, Padmanabhan Shyam, Rao Ravi, Suresh Aparnna, Bharath Dhana. Evaluation of the efficacy of a probiotic drink containing Lactobacillus casei on the levels of periodontopathic bacteria in periodontitis: A clinico‑microbiologic study. Indian Journal of Dental Research. 2015 Sept-Oct; 26(5): 462-468.