Comparative evaluation of hydroxyapatite and nano‑bioglass in two forms of conventional micro‑ and nano‑particles in repairing bone defects (an animal study).
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Date
2015-07
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Abstract
Context: Many synthetic bone materials have been introduced for repairing bone defects.
Aim: The aim of this study is to comparatively evaluate the efficacy of nano‑hydroxyapatite (HA)
and nano‑bioglass bone materials with their traditional micro counterparts in repairing bone
defects.
Materials and Methods: In this prospective animal study, four healthy dogs were included.
First to fourth premolars were extracted in each quadrant and five cavities in each quadrant
were created using trephine. Sixteen cavities in each dog were filled by HA, nano‑HA, bioglass,
and nano‑bioglass and four defects were left as the control group. All defects were covered by
a nonrestorable membrane. Dogs were sacrificed after 15, 30, 45, and 60 days sequentially. All
20 samples were extracted by trephine #8 with a sufficient amount of surrounding bone. All
specimens were investigated under an optical microscope and the percentage of total regenerated
bone, lamellar, and woven bone were evaluated.
Statistical Analysis Used: Data analysis was carried out by SPSS Software ver. 15 and
Mann–Whitney U‑test (α =0.05).
Results: After 15 days, the bone formation percentage showed a significant difference between
HA and nano‑HA and between HA and bioglass (P < 0.001). The nano‑HA group showed the
highest rate of bone formation after 15 days. Nano‑bioglass and bioglass and nano‑HA and
nano‑bioglass groups represented a significant difference and nano‑bioglass showed the highest
rate of bone formation after 30 days (P = 0.01). After 45 days, the bone formation percentage
showed a significant difference between nano‑bioglass and bioglass and between nano‑HA and
nano‑bioglass groups (P = 0.01).
Conclusions: Nano‑HA and nano‑bioglass biomaterials showed promising results when
compared to conventional micro‑particles in the repair of bone defects.
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Keywords
Bone substitute, bioglass, bone defect, hydroxyapatite
Citation
Nosouhian Saied, Razavi Mohammad, Jafari-pozve Nasim, Rismanchian Mansour. Comparative evaluation of hydroxyapatite and nano‑bioglass in two forms of conventional micro‑ and nano‑particles in repairing bone defects (an animal study). Indian Journal of Dental Research. 2015 July-Aug; 26(4): 366-371.