Neurodevelopmental Evaluation of Very Low Birth Weight Infants With Transient Hypothyroxinemia at Corrected Age of 18-24 Months.
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Date
2012-09
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Abstract
Objective: To perform neurodevelopmental evaluation at 18 to 24
months’ corrected age in very low birth infants (VLBW) with
transient hypothyroxinemia.
Design: Cohort study.
Setting: Maternity teaching hospital.
Patients: Premature infants who were previously evaluated for
thyroid hormone values in the first weeks of life were included.
Intervention: Data of these infants who weighed ≤1500 g and ≤32
weeks of gestation were retrieved for the current study. Available
subjects (n=56) were evaluated for neurodevelopmental status at
18 to 24 months of corrected age. Bayley Scales of Infant
Development –Second Edition (BSID-II) was performed to define
Mental developmental index (MDI) and Psychomotor
developmental index (PDI).
Results: The mean MDI and PDI scores were similar between the
infants with and without transient hypothyroxinemia of prematurity
(THOP) [79.9 ± 14.9 vs 70 ± 20.7, respectively (P=0.54); and 92.2
± 16.4 vs 85.6 ± 18.9, respectively (P=0.68)]. After adjustment for
gestational age and multiple prenatal, perinatal, and early and late
neonatal variables, THOP was not associated with an increased
risk of disabling cerebral palsy, or a reduction of MDI and PDI
scores.
Conclusions: THOP may not be an important cause of problems
in neurologic and mental development detected at the age of 18 to
24 months’ corrected age.
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Keywords
Neurodevelopment, Outcome, Newborn, Transient hypothyroxinemia of prematurity, Turkey
Citation
Dilli Dilek, Eras Zeynep, Andiran Nesibe, Dilmen Ugur, Sakrucu Evrim Durgut. Neurodevelopmental Evaluation of Very Low Birth Weight Infants With Transient Hypothyroxinemia at Corrected Age of 18-24 Months. Indian Pediatrics. 2012 September; 49(9): 711-715.