High Frequency Oscillatory Ventilation versus Synchronized Intermittent Mandatory Ventilation in Preterm Neonates with Hyaline Membrane Disease: A Randomized Controlled Trial.
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Date
2012-05
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Abstract
This randomized controlled study was conducted to compare the efficacy and safety of High
frequency oscillatory ventilation (HFOV) and Synchronized intermittent mandatory ventilation
(SIMV) in preterm neonates with hyaline membrane disease requiring ventilation. The
ventilation strategy in both the groups included achieving optimal lung recruitment and
targeted blood gases. 49 patients received HFOV and 61 SIMV. The baseline characteristics
were similar in both the groups. HFOV group demonstrated better early oxygenation, enabled
reduction in oxygenation index (OI) within 24 h of ventilation (difference in mean OI at 1, 6, &
24 h of ventilation: P=0.004 in HFOV, and 0.271 in SIMV group). Duration of hospital stay was
shorter in HFOV group (P=0.003). The complication rate and survival were similar in two
groups.
Description
Keywords
Complications, Hyaline membrane disease, Outcome, Neonates, Preterm, Ventilation
Citation
Singh S N, Malik G K, Prashanth G P, Singh Anita, Kumar Mala. High Frequency Oscillatory Ventilation versus Synchronized Intermittent Mandatory Ventilation in Preterm Neonates with Hyaline Membrane Disease: A Randomized Controlled Trial. Indian Pediatrics. 2012 May; 49(5): 405-408.