A School Outbreak of Shigella sonnei Infection in China: Clinical Features, Antibiotic Susceptibility and Molecular Epidemiology.
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Date
2010-04
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Abstract
Objective: To describe the clinical features of infection, and the
antibiotic susceptibility of epidemic strains, and investigate
plasmid maps and integrons of the isolates from an outbreak of
Shigella sonnei infection at an elementary school in southwest
China.
Study design: Cross-sectional study.
Setting: An elementary school and five hospitals in Chengdu in
southwest China.
Results: There were 1,134 students in the school. 937 (82.6%)
students had signs and symptoms. Of the 568 (60.6%, 568/937)
hospitalized students, 93.3% 86.8%, 72.4%, and 28.9% of the
hospitalized patients had diarrhea, fever, abdominal pain, and
vomiting, respectively. S. sonnei strains were isolated from the
stool samples of 36.0% (337/937) students. All of the outbreak
isolates had the same high-level antimicrobial resistance and
plasmid profiles, which were different from that of sporadic
strains. All the outbreak S. sonnei isolates were positive for the
integrin gene and contained class 2 integron; however, two
outbreak isolates contained class 1 and class 2 integrons.
Conclusions: Diarrhea, fever, and abdominal pain were the three
most common clinical manifestations observed in patients
infected with S. sonnei. High-level antibiotic resistance was
observed among Shigella species.
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Keywords
Antibiotic susceptibility, China, Outbreak, Shigella sonnei
Citation
Xiao G G, Fan J, Deng J J, Chen C H, Zhou W, Li X H, He Y W, Li H, Hu B, Qiao Y, Chen G H, Wan C M. A School Outbreak of Shigella sonnei Infection in China: Clinical Features, Antibiotic Susceptibility and Molecular Epidemiology. Indian Pediatrics. 2012 April; 49(4): 287-290.