Percutaneous computed tomography‑guided iodine‑125 seeds implantation for unresectable pancreatic cancer.
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Date
2015-12
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Abstract
BACKGROUND: To examine the safety and clinical efficacy of computed tomography (CT)‑guided radioactive iodine‑125 (125I) seeds implantation
for patients with unresectable pancreatic cancer. MATERIALS AND METHODS: A group of 26 patients with pathologically confirmed unresectable
pancreatic cancer underwent percutaneous CT‑guided 125I seeds implantation. Part of them received transarterial chemotherapy and/or percutaneous
transhepatic cholangial drainage before or after seeds implantation. The primary endpoints were the objective response rates, local control rates,
and overall survival. RESULTS: CT scan 2 months after treatment revealed complete response (CR) in 8 patients, partial response (PR) in 9 patients.
Overall response rate (CR + PR) is 65.38%. Local control rate was 88.46%. Median survival of the whole group was 15.3 months, whereas for
Stage III and IV was 17.6 and 9.1 months, respectively. The estimated 1‑year survival was 30.77%. CONCLUSIONS: We consider CT‑guided 125I
seeds implantation as a safe, effective, uncomplicated treatment for unresectable pancreatic cancer.
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Keywords
Brachytherapy, iodine, pancreas cancer, radioisotopes
Citation
Liu B, Zhou T, Geng J, Zhang F, Wang J, Li Y. Percutaneous computed tomography‑guided iodine‑125 seeds implantation for unresectable pancreatic cancer. Indian Journal of Cancer. 2015 Dec; 52(6)Suppl_2: s69-s74.