Pesticide (Endosulfan) Levels in the Bone Marrow of Children with Hematological Malignancies.
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Date
2012-02
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Abstract
Objectives: (1) To confirm the presence of Pesticide
(Endosulfan) residues in the bone marrow (BM) of
children with acute hematological malignancies and
compare them with controls. (2) To ascertain if children
with Endosulfan in their marrow reside in areas sprayed
with Endosulfan.
Study design: Case control study
Setting: Pediatric oncology unit of a medical college
teaching hospital in Dakshina Kannada district of
Karnataka.
Subjects: 26 patients with proven hematological
malignancy and 26 age matched controls suffering from
benign hematological disease.
Methods: Endosulfan residues in the BM were estimated
by gas chromatography – mass spectrometry (Minimum
detection limit 10ng/mL). The subject’s geographical area
of location (residence) was determined to see whether
they belong to sprayed area or not. The Chi-square test
was applied to see an association between exposure
R E S E A R C H P A P E R
status and hematological malignancy.
Results: A total of 52 children were enrolled of which 26
were study cases and 26 were controls. Of the study and
control groups, 84.7% and 73.1%, respectively were from
exposed areas. The major (88.4%) illness in the study
group was ALL, while ITP (50%) occurred most frequently
in the control group. Six out of 26 study cases tested
positive for endosulfan in the BM, against 1 out of 26
controls (P = 0.042). The Odds ratio was 7.5. All children
who had endosulfan in the bone marrow originated from
areas, where endosulfan is still being used.
Conclusions: Children with hematological malignancy
had raised levels of endosulfan in the bone marrow
compared to those without. All the children with raised
bone marrow Endosulfan levels were found to be from
areas exposed to the pesticide.
Description
Keywords
Endosulfan, bone marrow, hematological, malignancy, India
Citation
Rau A T K, Coutinho Anita, Avabratha K Shreedhara, Rau Aarathi R, Warrier Raj P. Pesticide (Endosulfan) Levels in the Bone Marrow of Children with Hematological Malignancies. 113-117.