Primary Biliary Cirrhosis and Mitral Stenosis: A Rare Association.
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Date
2015-09
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Abstract
Primary biliary cirrhosis is a rare cause of chronic liver disease in Myanmar. It usually presents with pruritus and fatigue in a middle-aged female before the appearance of jaundice. This case illustrates a woman presenting with 15 years of pruritus and 5 years of intermittent jaundice. She had no risk factors for viral hepatitis and was a non-drinker. Multiple consultations were done and treated as a chronic liver disease without probing further for the etiology. Persistently high alkaline phosphatase of biliary origin prompted us to test for anti-mitochondrial antibodies which were positive for M2 subtype. Furthermore, she was found to have clinical and echocardiographic evidence of mitral stenosis (MS). MS is usually a consequence of post-streptococcal rheumatic carditis. Molecular mimicry is the common mechanism in the pathogenesis of both conditions. Her symptoms improved after ursodeoxycholic acid treatment.
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Keywords
Cirrhosis, Mitral stenosis, Primary biliary cirrhosis, Pruritusthe
Citation
Ni Han, Htet Aung. Primary Biliary Cirrhosis and Mitral Stenosis: A Rare Association. IJSS Case Reports & Reviews. 2015 Sept; 2(4): 1-4.