The Impact of Iron Deficiency on HBA2 Level in Beta Thalassemia Minor in Sulaimani Northeastern Iraq.
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Date
2015-10
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Abstract
Background: HbA2 plays a key role in screening programs for beta thalassemia because a small increase in this
fraction is the most important marker of beta thalassemia heterozygous carriers. The potential impact of
coincident iron deficiency on HbA2 based identification of beta thalassemia minor is worrisome issue for
screening laboratories, this is especially true for resource-constrained settings where iron deficiency is wide
spread and molecular confirmatory tests for borderline HbA2 values may be unavailable.
Objective: the aim of this study is to evaluate the effect of iron deficiency on HbA2 level in order to improve the
detection of beta thalassemia trait with or without iron deficiency in our population.
Materials and Method: In this study 145 individuals were enrolled including normal controls (50), beta
thalassemia minor (50) and coincident beta thalassemia with iron deficiency cases (45). Complete blood count,
serum iron, total iron binding capacity and HbA2 with HbF estimation were done for every individual.
Result: The mean HbA2 level was (2.4± 0.4) in control, (5.2 ± 0.9) in beta thalassemia minor and 5.1± 0.9 in
coincident iron deficiency with beta thalassemia minors. All hematological parameters were significantly lower
in beta thalassemia minor and coincident iron deficiency with beta thalassemia minor in comparison to the
control group .Mean HbA2 level did not show a significant difference in thalassemia minor (5.2±0.9) when
compared with the mean HbA2 levels in coincident iron deficiency with beta thalassemia minor.
Conclusion: The presence of iron deficiency did not preclude the detection of beta thalassemia minor in our
population.
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Keywords
HbA2, thalassemia minor, iron deficiency, anemia
Citation
Kamal Awaz Ahmed, Jalal Sana Dlawar, Mohammed Dler Jaza. The Impact of Iron Deficiency on HBA2 Level in Beta Thalassemia Minor in Sulaimani Northeastern Iraq. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Oct-Dec; 6(4): 59-62.