Effect of Phyllanthus Amarus on Haloperidol Induced Catalepsy in Experimental Animal Models.
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Date
2015-07
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Abstract
Objectives: The aim of the study was to investigate the anticataleptic effect of Phyllanthus amarus ethanolic
extract in Swiss albino mice.
Methods: The ethanolic extract of leaves of Phyllanthus amarus [PAEE] at a dose of 100mg/kg/body weight was
administered orally for ten days. On tenth day, one hour later Haloperidol [1 mg/ kg IP] was administered to induce
catalepsy.
Results: The results indicate that induction of catalepsy by Haloperidol in Swiss albino mice was significantly
prevented by PAEE.
Conclusions: The anticataleptic activity of Phyllanthus amarus can be due to its effect on brain neurotransmitters
or due to antioxidant property.
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Keywords
Haloperidol, catalepsy, Swiss albino mice, PAEE, Anticataleptic
Citation
Deepa B, Joy Anu E, Manikkoth Shyamjith. Effect of Phyllanthus Amarus on Haloperidol Induced Catalepsy in Experimental Animal Models. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Jul-Sept; 6(3): 199-203.