Early Neonatal Morbidities in Late Preterm Infants.
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Date
2011-08
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Abstract
Objectives: To compare early neonatal morbidity (within
first 7 days of life) in late preterm infants with term infants.
Study design: Prospective cohort study.
Subjects: All live inborn late preterm infants (34 0/7 to 36
6/7 weeks) and term infants (37 0/7 to 41 6/7 weeks).
Outcome: Any of the predefined medical conditions listed
in the study, resulting in post- delivery inpatient hospital
observation, admission, or readmission in first 7 days of
life.
Results: 363 late preterm infants and 2707 term infants
were included in study. Two hundred fifty seven (70.8 %) of
late preterm and 788 (29.1%) of term infants had at least
one of the predefined neonatal conditions. Late preterm
infants were at significantly higher risk for overall morbidity
due to any cause (P<0.001; adjusted Odds Ratio (OR):
5.5; 95% CI: 4.2-7.1), respiratory morbidity (P<0.001;
adjusted OR: 7.5; 95% CI: 4.2-12.3), any ventilation (non
invasive or invasive) (P=0.001; adjusted OR: 4.2; 95% CI:
2-8.9), jaundice (P<0.001; adjusted OR: 3.4; 95% CI: 2.7-
4.4), hypoglycemia (P<0.001; adjusted OR: 4.5; 95% CI:
2.6-7.7), and probable sepsis (P<0.001; adjusted OR: 3.2;
95% CI: 1.6-6.5). The incidence of morbidities increased
from 23% at 40 weeks to 30%, 39.7%, 67.5%, 89% and
87.9% at 38, 37, 36, 35 and 34 weeks, respectively
(P<0.001).
Conclusion: Compared with term infants, late preterm
infants are at high risk for respiratory morbidity, need of
ventilation (non invasive or invasive), jaundice,
hypoglycemia, sepsis, and probable sepsis. All gestations
except 39 weeks were at significantly higher risk for
morbidity with 40 weeks as reference term.
Description
Keywords
India, Late preterm infants, Neonatal morbidity, Outcome
Citation
Jaiswal Ashish, Murki Srinivas, Gaddam Pramod, Reddy Anupama. Early Neonatal Morbidities in Late Preterm Infants. Indian Pediatrics. 2011 August; 48(8): 607-611.