Impact of Two Regimens of Vitamin D Supplementation on Calcium - Vitamin D - PTH Axis of Schoolgirls of Delhi.
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Date
2010-09
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Abstract
Objective: To determine the efficacy of supplementation
with oral vitamin D3 (cholecalciferol) on bone mineral
biochemical parameters of school-going girls.
Setting: Government school (government-aided) and
Private school (fee paying) in Delhi.
Design: Randomized controlled trial.
Intervention: Cholecalciferol granules (60,000 IU) orally
with water, either once in two months (two-monthly D3
group) or once a month (one-monthly D3 group) for one
year.
Participants: 290 healthy schoolgirls (6-17 y), 124 from
lower socioeconomic strata (LSES) (attending
government schools) and 166 from upper socioeconomic
strata (USES) (attending private schools).
Outcome measures: Serum 25(OH)D, calcium,
phosphorus, parathyroid hormone, and alkaline
phosphatase levels at 6 and 12 months after start of
supplementation.
Results: At baseline, 93.7% schoolgirls were vitamin D
deficient [25(OH)D<50 nmol/L]. While significant increase
in serum calcium and decrease in alkaline phosphatase
levels was noted in both groups with both interventions,
PTH response was inconsistent. In LSES subjects, twomonthly
D3 and one-monthly D3 supplementation resulted
in a significant increase in serum 25(OH)D levels by 8.3
nmol/L and 11.0 nmol/L, respectively at 6 months
(P<0.05). Similarly, the increase in the two intervention
arms in USES subjects was 10.5 nmol/L and 16.0 nmol/L,
respectively (P<0.05). In both groups, this increase in
serum 25(OH)D levels persisted at 12 months (P<0.05).
Despite supplementation with 60,000 IU of Vitamin D3
(monthly or two-monthly), only 47% were vitamin D
sufficient at the end of one year.
Conclusions: 60,000 IU of cholecalciferol, monthly or
two-monthly, resulted in a significant increase in serum
25(OH)D levels in vitamin D deficient schoolgirls.
Description
Keywords
Cholecalciferol, India, Supplementation, Schoolgirls, Vitamin D
Citation
Marwaha Raman K, Tandon Nikhil, Agarwal Neha, Puri Seema, Agarwal Rashmi, Singh Satveer, Mani Kalaivani. Impact of Two Regimens of Vitamin D Supplementation on Calcium - Vitamin D - PTH Axis of Schoolgirls of Delhi. Indian Pediatrics. 2010 Sept; 47(9): 761-769.