Association of Calcitonin Receptor 1340 C>T Polymorphism with Periodontitis Susceptibility.
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Date
2015-04
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Abstract
Background: Periodontitis is a common multifactorial oral disease and a major cause of tooth loss
among adults. The present study was aimed to investigate the role of calcitonin receptor (CTR) gene polymorphism
in the causation of periodontitis.
Materials and Methods: A total of 112 subjects comprising of 62 patients and 50 controls were enrolled and
recruited from various dental clinics in and around Hyderabad, India. Two milliliter of blood sample was collected
from all the subjects. Following extraction of DNA, genotyping for CTR 1340 C>T was performed by PCR-RFLP.
Results: The frequency of CC, CT and TT genotypes in patients was 45%, 42% and 13% while in controls it was
56%, 32% and 12%. The frequency of C and T allele was 0.66 and 0.34 in patients whereas it was 0.72 and 0.28 in
controls. The genotype and allele frequencies did not vary between the groups. The genotype frequencies among
male and female sub-types revealed a statistically significant difference in female subgroup. The CT genotype and T
allele revealed an OR value of 5.62 and 2.40 respectively.
Conclusion: Our study revealed a significant association of this SNP with periodontitis only in females. It also
highlights the predisposing role of CT genotype and T allele in the causation of periodontitis. However, replicative
studies on the influence of this polymorphism in different ethnic groups may identify the potentiality of this SNP
towards periodontitis.
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Keywords
Periodontitis, Calcitonin receptor, Signal transduction, Bone Mineral Density, Bone resorption
Citation
Sunitha T, Deepika M L N, Deepika G, Srinadh B, Sujatha M, Jyothy A. Association of Calcitonin Receptor 1340 C>T Polymorphism with Periodontitis Susceptibility. International Journal of Applied Biology and Pharmaceutical Technology. 2015 Apr-June; 6(2): 217-222.