Cytomegalovirus Infection in Six Neonates.
Loading...
Date
2010-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Neonatal cytomegalovirus (CMV) infection is common, has myriad presentations
and severe sequelae. Six neonates clinically suspected of CMV infection were
confirmed by qualitative PCR (Digene) and evaluated. Those with persistent
viremia were treated with Ganciclovir intravenously for 4-6 weeks, and continued
orally, if required, with close monitoring. All had prolonged jaundice, hepatosplenomegaly
and hematological manifestations in the acute stage. Complications
included developmental delay (66%), sensorineural hearing loss (SNHL) (33%),
chorioretinitis and obstructive jaundice (18% each). Three cleared viremia
spontaneously. The remaining were offered Ganciclovir. One declined, and two
completed therapy with clinical resolution and no adverse events. Accurate
diagnosis of neonatal CMV enables appropriate treatment with Ganciclovir, which
can reverse end-organ damage and limit sequelae.
Description
Keywords
CMV, Ganciclovir, Management, Neonate
Citation
Yadav S S, Narula G, Narayan s, Biswas S, Gupta G. Cytomegalovirus Infection in Six Neonates. Indian Pediatrics. 2010 Feb; 47(2): 174-175.